The workshop will serve to explore and accelerate plans for a Knowledgebase Portal (KB Portal). The KB Portal that is under development will enable scientists to examine the results of the work of the PSI projects from many points of view and in turn, advance our understanding of biology. In developing the Knowledgebase Portal, we are considering the overall goals of the PSI and how to enable the most effective usage and strongest impact of PSI data.

We would like to explore the following areas at the workshop:

• How do we create a research environment that facilitates the prediction and determination of the functions for the structures of unknown function determined by the PSI centers?

• What tools are currently available to understand the relationships among structure, sequence, and function? How can (should) these tools be improved? What processes and tools would facilitate the creation of other important generalizations from PSI data?

• What are the needs of the broader biological community with respect to accessing and understanding the data produced by the PSI centers? How can we enhance impact, or in practical terms, how can we expand usage of the data by that broader community?

The workshop is hosted by JCSG and UCSD's Calit2. Funding for the workshop has been made available by the National Institute of General Medical Sciences (NIGMS), as part of the second phase of the Protein Structure Initiative (PSI) of the NationalInstitutes of Health. (U54 GM074898).